Sedatives are a category of drugs that slow brain activity. Rocuronium is a nondepolarizing paralytic agent that induces muscle paralysis by competitive antagonism at the acetyl-cholinergic receptor. alcohol or other sedative drug use, and concurrent therapy with opioids. Paralytic agents were titrated to a train-of-four response (2/4 at 50 mA) on a protocol. RSI incorporates a rapidly acting sedative (ie, induction) agent, in addition to a neuromuscular blocking (ie, paralytic) agent, to create optimal intubating conditions. While physical adjuncts like securing the tube, in line suctioning, and elevating the head of the bed are part of general post intubation management, better understanding of analgesics and sedatives have offered newer approaches. Dosing of rocuronium can vary from 0.6–1.2 mg/kg. Patients with severe brain injury (GCS ≤ 8) were excluded. Reversal of rocuronium can be accomplished more rapidly with edrophonium than with neostigmine at a return to 25% of control {36} {37}. Post-Intubation Sedation and Analgesia Background: The immediate post intubation period in the ED is a critical time for continued patient stabilization. In most circumstances, emergency clinicians use rapid sequence intubation (RSI) to accomplish this task. Finally, the occurrence of hypotension or cardiac arrest post-etomidate administration was also collected. Sedative drugs are helpful for treating anxiety and sleep problems, but using them can lead to dependence or addiction. Reversal of rocuronium blockade should not be attempted until demonstration of some spontaneous recovery from neuromuscular blockade {01}. Start studying Analgesic, Sedative, Antipsychotic, and Paralytic in Critical Care. Learn vocabulary, terms, and more with flashcards, games, and other study tools. INTRODUCTION — The first task of any clinician managing an acutely unstable patient is to secure the airway. Months three and four titrated sedative infusions to a BIS value between 70 and 80. In months one and two, sedatives were titrated to patient comfort guided by vital sign changes after stimulation. Sedative and paralytic agents administered peri- and postintubation by the transport team, time of administration, time of intubation, and paralytic dose were collected. Rocuronium is recommended for intravenous administration only {01}.